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pentobarbital will reduce the level or impact of montelukast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can decrease panobinostat stages by ~70% and bring on t